Now, 12 years have passed. The “golden industrial chain†created by “Tan Bold†has become the most core, most luxurious and most profitable business for commercial vehicles in China. The power of the “Golden Powertrain†and the 100-year-old European and American engine giants have finally put aside their positions and seriously studied “Tan Xuguang’s strategy cubeâ€. What is the power of Weichai's "Golden Powertrain"? Looking at the report card for the first half of 2017, you will know how strong Weichai’s “Golden Powertrain†is! Weichai Group's transcripts for the first half of 2017 Weichai Engine Leads Industry High-end Products Experts who are concerned about the industry all year round are aware of the fact that weichai has been the slowest in the downturn of the industry; when the industry recovers, weichai has grown fastest. The secret behind this is that Weichai uses research and development to create high-end power and drive development with innovation. Compared to other companies, the "Sixth National" engine has just started the ignition and the batches are still not in the same period. Weichai "State VI" is already in place, waiting for "starting guns." Weichai's Fast Transmission is No. 1 in the world for 11 consecutive years In 2005, Fast sold less than 130,000 units, and then developed rapidly. For the past 11 years, the production and sales volume of mechanical transmissions has been ranked first in the world. In the first half of 2017, production and sales volume increased by 73.8% year-on-year. The Weichai Group's Shaanxi Heavy Duty Holding "Golden Industrial Chain" follows the first echelon Shaanxi Heavy-duty Auto has achieved the transformation of its full range of business such as dump trucks, tractors and trucks; in refining the market, effective breakthroughs have been made in markets such as cold chain, hazardous chemicals, and sanitation; and port vehicles and muck trucks are the first in the industry. Weichai's Axle Development Chain Business of Weichai Substantially Improves Hande Axle, the business expanded to heavy truck bridges, engineering axles, passenger car bridges, medium trucks, electric axles and other products. Some people think: Weichai is "an engine company." Tan Xuguang said that we are no longer a single engine company, but a related diversified industrial group. In Weichai's view, the engine is only one of the group's business modules. In Weichai's view, the engine is only one of the group's business modules Macitentan API And Intermediates
Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.
Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an endothelin receptor antagonist, an antihypertensive agent and an orphan drug. It is an organobromine compound, a member of pyrimidines, an aromatic ether, a ring assembly and a member of sulfamides. It derives from an ethylene glycol and an ACT-132577.
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In 2005, Weichai purchased the torch of Hunan for a strategy of 1.02338 billion yuan, shocked the industry and stirred up the structure of China's heavy truck. Tan Xuguang has therefore been dubbed "Tan bold".