Since the reform and opening up, China’s economy has been developing rapidly. The level of people’s lives has been getting better and better, and the catering industry has gradually become one of China's pillar industries. Because people always have to eat, no one can escape three meals a day. There are a total of nearly 3.5 million homes in China, including big restaurants or small restaurants. This does not include street food stalls. So we can imagine how amazing the food waste generated each day will be. Therefore, in order to collect these food wastes and dispose of them, kitchen garbage trucks that are specially used to transport kitchen waste are also rapidly developing. Many people should have seen the kitchen garbage truck. It is a large truck loaded with a large tank containing food waste. This kind of car is especially seen in school canteens and restaurant restaurants. The kitchen garbage truck is also a type of garbage truck, except that it is used to collect domestic food garbage or urban sludge garbage. The kitchen garbage truck is used by using a conveyor belt to transport the barrel-loaded kitchen waste slowly upwards, and then dumping the garbage on the top of the tank into a large can containing garbage. The kitchen garbage truck will use the pusher to squeeze solid waste and liquid waste. The separated solids will be compressed in the tank, and the liquid will be discharged into the recovery tank below the tank. The entire process of separation is entirely mechanically automated. Then the kitchen garbage truck will transport the kitchen garbage to a special place to dispose of the garbage, which solves the odor of the kitchen garbage, minus the disgusting odor of the kitchen garbage that is filled in the air. Reduces the possibility of breeding of bacterial mosquitoes. Greatly improved the environment around us and reduced the harmfulness of the spread of pollution. Food kitchen garbage cans are very closed and easy to handle. Received wide acclaim from the community. With the existence of kitchen garbage trucks, the surrounding environment of our lives has been greatly improved, and the harmfulness of manual handling of kitchen garbage has also been reduced. In short, with the progress of society, everything around us is developing in a more humanized, more automated and safer direction. Pyrimidine series intermediates
Pyrimidine, also known as 1,3-diazepine, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by replacing 2 carbons in the meta-position of benzene with 2 nitrogen atoms, and is a diazine. Like pyridine, pyrimidine retains its aromaticity.
Introduction
Name: Pyrimidine
Molecular formula: C4H4N2
Molar mass: 80.09 g/mol
Density: 1.016 g/ml
Melting point: 20 - 22 °C
Boiling point: 123 - 124 °C
CAS Number: 289-95-2
EINECS Number: 206-026-0
SMILES: C1=NC=NC=C1
Application
(1) Anticancer drugs. In the selection of anticancer substances, it is crucial that there are significant differences between tumor tissues and normal tissues, that is, they have a certain ability to recognize target cells. Porphyrin compounds have special affinity for cancer cells due to their unique structures, and they can selectively stay in cancer tissues. The research of it as a localizing agent and a drug for diagnosis and treatment of cancer has already aroused great interest of chemists, medical scientists and biologists. 5-Fluorouracil is a widely used anti-metabolite and anti-tumor drug in clinic. It has inhibitory effect on various tumors. It has good clinical effect in the treatment of colorectal cancer, gastric cancer, breast cancer and other cancers. Polyesters, polyester hydrocarbons, polyester amides, deoxyribonucleic acid, furans, 5-fluorouracil derivatives linked to nitroxide radicals all have antitumor effects.
(2) Anti-AIDS drugs. Viral diseases have become one of the most harmful diseases to human beings, especially the spread of AIDS, which has aroused widespread concern. There are many kinds of anti-AIDS drugs that have been approved by the US Food Administration (FDA), many of which are nucleoside compounds. In order to reduce the toxicity of drugs and improve their efficacy, scientists have begun to turn their attention to the study of non-nucleoside compounds, and such compounds have become the focus of antiviral drug research.
Synthetic method
Pyrimidines and various substituted pyrimidines are synthesized in a variety of ways. For example, barbituric acid (2,4,6-trihydroxypyrimidine) can be obtained by the condensation of urea and diethyl malonate under the action of sodium alkoxide. Barbituric acid and phosphorus oxychloride are heated together to obtain 2,4,6-trichloropyrimidine, which reacts with sodium methoxide to obtain trimethoxypyrimidine. Chloropyrimidines react with ammonia or primary and secondary amines to generate the corresponding aminopyrimidines. The derivatives of pyrimidine, cytosine, uracil and thymine, are the constituent parts of nucleic acid and deoxynucleic acid, and the pyrimidine part in the vitamin B1 molecule is a 4-amino-2-methyl-5-pyrimidine methyl group. Many oral long-acting sulfa drugs are derivatives of pyrimidine and its isomers.
The 2,4-dichloropyrimidine is prepared by reduction reaction in the presence of palladium, magnesium oxide and activated carbon.
Pyrimidine Series Intermediates,2-Chloro-5-Methylpyrimidine,5-Bromo-2-chloropyrimidine,2 4-Dichloro-5-Methylpyrimidine Fuxin Custchem Fine Chemical Co., Ltd. , https://www.custchemvip.com