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[ Instrument R&D of Instrument Network ] Monopod lactone is a new type of plant hormone, which plays a key role in the establishment of plant type, regulates the growth and development of plants and the ability to adapt to drought, low phosphorus, low nitrogen and other adversity, and it is suitable for crops. Improving production has important value. But the hormone also stimulates the germination of parasitic weed seeds, causing serious crop yield reduction. Therefore, the research on the signal pathway of monopods has great scientific significance and application value.
On June 11, Li Jiayang, a member of the Chinese Academy of Sciences and a researcher at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, published a research paper entitled "Transcriptional regulation of strigolactone signalling in Arabidopsis" in Nature, systematically identifying the early stage of Arabidopsis monopod gold lactone Responding to genes, elucidating the molecular mechanism of monopod lactone to regulate the number of branches, leaf shape and anthocyanin accumulation, breaking the bottleneck of the monopod lactone signaling pathway; further found that SMXL6,7,8 can regulate themselves as transcription factors Transcription, at the same time as a transcription suppressor protein, regulates branching and other developmental processes, revealing a brand new mechanism of plant hormone signal transduction.
Li Jiayang's team has long been engaged in the synthesis and signal transduction of monopods, and found that monopods can induce the formation of its receptor D14 and F-box protein D3/MAX2 and inhibitor protein D53/SMXL2,6,7,8 The complex initiates signal transduction, induces ubiquitination modification-mediated protein degradation in D53/SMXL2,6,7,8, relieves transcriptional suppression of downstream genes, and regulates plant type and crop yield (Lin et al., 2009, Plant Cell; Jiang et al., 2013, Nature; Wang et al., 2015, Plant Cell; Song et al., 2017, Cell Research; Duan et al., 2019, PNAS; Wang et al., 2020, Plant Cell). Recently, research with collaborators found that the monopod lactone pathway is widely used in the rice "green revolution" and is very important for the stable production and wide adaptability of rice (Wang et al., 2020, Mol Plant).
However, only a few early response genes have been identified, which is far from enough to explain the important regulatory role of pediolides in many aspects of plant growth and development; the artificial analogue of pediolides rac-GR24 It can activate the two signal pathways of monopod and karrikin, so that the identified response genes are not necessarily located in the monopod signal.
In order to break through the bottleneck of the study on the signal of monopod lactone, this study synthesized the four enantiomers of GR24 and found that GR244DO can specifically activate the Arabidopsis thaliana Foot gold lactone signal transduction, and systematically identified 401 monopod gold lactone early response genes. The study found that monopod lactone upregulates the expression of HB40 by activating BRC1 expression, thereby increasing the content of ABA in lateral buds to inhibit branch development; upregulating the expression of TCP1 to promote leaf elongation; by activating PAP1, PAP2, MYB113 and MYB114 Expression, up-regulated the expression of anthocyanin synthesis genes DFR, ANS and TT7 to promote anthocyanin synthesis and accumulation.
This study proposes a brand new mechanism of plant hormone signal transduction, which provides a new way of exploring the mechanism of hormone action. The research reveals the transcriptional regulatory network of the monopod lactone signaling pathway, which comprehensively analyzes the molecular mechanism of the monopod lactone regulating plant growth and development and environmental adaptation, reveals the symbiotic mechanism of plants and arbuscular fungi to cultivate high-yield stress resistance, Nutritionally efficient, anti-parasitic crops have guiding significance.
Dr. Wang Lei and associate researcher Wang Bing of the Institute of Genetic Development are co-first authors of the paper, and Li Jiayang and Wang Bing are co-corresponding authors. Dr. Chu Jinfang, a doctor of plant hormone platform, Xiong Guosheng, a professor at Nanjing Agricultural University, and Yang Jun, a researcher at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, participated in the research. The research was supported by the National Natural Science Foundation of China and the Youth Promotion Association of the Chinese Academy of Sciences.